Aβ/tau aggregation-IN-1 - ≥95% , CAS No.2252162-81-3

CAS: 2252162-81-3 Cat. No.: A646131 분자식: C₂₅H₂₁IN₂O 분자량: 492.35

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

개요

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

In Vitro

Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ 1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ 1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ 1-42 and tau. The K D value of Aβ/tau aggregation-IN-1 with Aβ 1-42 is 160 μM. The K D value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ 1-42 and tau through noncovalent interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci.

Form:Solid

IC50& Target:Kd: 160 μM (Aβ1-42),Kd: 337 μM (tau)

Specifications

사양 및 순도

≥95%

생화학 및 생리적 메커니즘

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier

보관 조건

Store at 2-8°C,Protected from light,Desiccated

배송

Wet ice

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작업 유형

INHIBITOR

순수함

≥95%

이름과 식별자

• 분자량: 492.35

화학 및 물리적 특성

• 용해성: DMSO : 33.33 mg/mL (67.70 mM; ultrasonic and warming and heat to 60°C)