Acevaltrate - ≥99% , CAS No.25161-41-5

CAS: 25161-41-5 Cat. No.: A649443 분자식: C₂₄H₃₂O₁₀ 분자량: 480.50 PubChem CID: 65717

등급 & 순도 ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Acevaltrate inhibits the Na + / K + -ATPase activity in the rat kidney and brain hemispheres with IC 50 s of 22.8 μM and 42.3 μM, respectively

In Vitro

Acevaltrate differentiallys inhibit the activity of rat P-type ATPases in vitro. 60.7±7.3% inhibition of the rat H + /K + -ATPase is achieved at 100 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 22.8±1.1 μM (Na + /K + -ATPase, in rat kidney), 42.3±1.0 μM (Na + /K + -ATPase, in rat brain hemispheres)

사양

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

Acevaltrate inhibits the Na + / K + -ATPase activity in the rat kidney and brain hemispheres with IC 50 s of 22.8 μM and 42.3 μM, respectively.

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

이성체 SMILES

CC(C)CC(=O)O[C@H]1[C@H]2C(=C[C@@H]([C@]23CO3)OC(=O)CC(C)(C)OC(=O)C)C(=CO1)COC(=O)C

PubChem CID

65717

분자량

480.50

관련 대상(인간)

HCT-8 (3484 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (208.12 mM; Need ultrasonic)
• 분자량: 480.500 g/mol
• XLogP3: 0.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 13
• Exact Mass: 480.2 Da
• Monoisotopic Mass: 480.2 Da
• Topological Polar Surface Area: 127.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 915.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1