GRADE & PURITYBioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.Native?Native grade — protein/biomolecule in its natural (non-recombinant, non-denatured) form. Use when native structure and activity are required.High Performance?High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short.EnzymoPure™?EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance.from Human plasma; Pre-lyophilization Protein Concentration: See COA
Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, from Human plasma; Pre-lyophilization Protein Concentration: See COA ActiBioPure™,Bioactive,High Performance,Native,EnzymoPure™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
Activated Protein C (APC) is a serine protease derived from the two chain vitamin K dependent zymogen, Protein C. APC inhibits blood coagulation through the selective inactivation of the cofactors Va and VIIIa. APC is prepared from protein C by activation with purified thrombin. This thrombin is removed after activation by ion exchange chromatography. Activated Protein C purity is determined by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol.
Buffer composition = 20 mM Tris-HCl/0.1 M NaCl/ pH 7.4
Extinction Coefficient (1%) = 14.5
Molecular Weight = 56,000 daltons
The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
Specifications
Product Name
Activated Protein C (APC), CAS No.925910-74-3
동의어
Human Activated Protein C | Human Activated Protein C Native Protein | Vitamin K-dependent protein C | protein C, inactivator of coagulation factors Va and VIIIa | PROC | PC | APC | PROC1 | THPH3 | THPH4
등급
ActiBioPure™, Bioactive, High Performance, Native, EnzymoPure™
사양 및 순도
Bioactive, ActiBioPure™, Native, High Performance, EnzymoPure™, from Human plasma; Pre-lyophilization Protein Concentration: See COA
생화학 및 생리적 메커니즘
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Miscellaneous:
생체 활성
See COA
예상 분자량
56 kDa
CAS
925910-74-3
분자 유형
Enzyme
Product Line
생물 제품
보관 및 배송
집중력
from Human plasma; Pre-lyophilization Protein Concentration: See COA
재구성
We suggest hydrating the protein with a good quality water to the original volume (See COA). After hydration aliquot into a useful (one time use) size and freeze at -80℃.
보관 조건
Store at 2-8°C
배송
Wet ice
안정성 및 스토리지
Store at 2-8℃ long term. Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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