AD57 - 10mM in DMSO , CAS No.1093380-42-7

CAS: 1093380-42-7 Cat. No.: A656632 분자식: C₂₂H₂₀F₃N₇O 분자량: 455.44

등급 & 순도 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Braf

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity.

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

분자량

455.44