10mM in DMSO 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
Store at -80°C Dry ice packs + Cold packs 출고. 정확한 사양은 로트별 COA를 확인하세요.
SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
AGN 192836 is a potent and selective α2 adrenergic agonist with EC 50 s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
In Vitro
Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:α adrenergic receptor
위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
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