AGN 194078 - ≥98% , CAS No.321995-62-4

CAS: 321995-62-4 Cat. No.: A647818 분자식: C₂₂H₂₃F₂NO₄ 분자량: 403.42

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a K d value of 3 nM, while being unable to bind to RARβ and binding only very weakly (K d =5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC 50 value of 112 nM, but only activated\nRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Kd: 4 nM (RARα), EC50: 140 nM (RARα)

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

AGN 194078 is a selective RARα agonist with a K d and EC 50 of 3 and 112 nM, respectively.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

AGONIST

순수함

≥98%

이름과 식별자

분자량

403.42

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (247.88 mM; Need ultrasonic)