Anatabine dicitrate - ≥99% , CAS No.A659426

CAS: A659426 Cat. No.: A659426 분자식: C₂₂H₂₈N₂O₁₄ 분자량: 544.46

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

개요

Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre

Appearance:Solid

IC50& Target:NF-κB Amyloid-β (Aβ) α4β2 nAChR

In Vitro:Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hou

In Vivo:Anatabine (0.5-2mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ 1-40 and Aβ 1-42 levels in a transgenic mouse model of Alzheimer's disease. MCE has not independently confirmed th

Biological Activity:Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid pre

Specifications

사양 및 순도

≥99%

보관 조건

Store at 2-8°C,Desiccated

배송

Wet ice

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순수함

≥99%

이름과 식별자

정식 스마일

O=C(CC(C(O)=O)(O)CC(O)=O)O.O=C(CC(C(O)=O)(O)CC(O)=O)O.[C@@H]1(C2=CC=CN=C2)CC=CCN1

분자량

544.46

화학 및 물리적 특성

• 용해성: H2O : 100 mg/mL (183.67 mM; Need ultrasonic) DMSO : 30 mg/mL (55.10 mM; Need ultrasonic)