Anticancer agent 73 - 10mM in DMSO , CAS No.124811-87-6

CAS: 124811-87-6 Cat. No.: A654850 분자식: C₁₄H₁₅NO₄ 분자량: 261.27

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo.

In Vitro

Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the expression of E-cadherin and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells; inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting miRNA biogenesis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice MCE has not independently confirmed the accuracy of these methods. They are for reference only.

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. An

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

분자량

261.27