10mM in DMSO 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
Store at -80°C Dry ice packs + Cold packs 출고. 정확한 사양은 로트별 COA를 확인하세요.
SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies
In Vitro
Apinocaltamide (Compound 66b) blocks Ca v 3.1, Ca v 3.2, Ca v 3.3, Ca v 1.2 with IC 50 s of 6.4, 18, 7.5 and 2410 nM, respectively. Apinocaltamide blocks recombinant channel hCa v 3.3 potently with marked voltage-dependency (K r ≈1500 nM and K i ≈20 nM). Apinocaltamide blocks currents through hK v 11.1-hERG channels with an IC 50 of 5.5 μM. Apinocaltamide also inhibits P450 enzymes with IC 50 s of 14, 15, 22, 25, 51 and 52 μM for CYP2C8,CYP2D6 CYP2C9, CYP2C19, CYP3A4, and CYP2B6, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Apinocaltamide (Compound 66b, 100, 300 mg/kg, p.o., measured 12 hours later) potently decreases the cumulative duration of absence-like seizures in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male juvenile DBA/2J mice (22-24 days old) Dosage: 100, 300 mg/kg, 1 hour or 3 hours before exposure to the stimulus. Administration: P.O., for 12 hours Result: Decreased the cumulative duration of absence-like seizures over the next 12 h period by 93%.
IC50& Target:Ca v 1.2 2410 nM (IC 50 ) Ca V 3.1 6.4 nM (IC 50 ) Ca v 3.2 18 nM (IC 50 ) Ca V 3.3 7.5 nM (IC 50 )
위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 날짜 | 항목 |
|---|---|---|---|
 J2613710 | Certificate of Analysis | Oct 16, 2026 | A655794 |
