AR-M1000390 - Moligand™ , Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor, CAS No.A607733, Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor
AR-M1000390 - Moligand™ , Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor, CAS No.A607733, Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
리뷰
고객 리뷰
Application Protocols
No item-specific, validated protocols are provided in the Product Data. The following are general, widely used procedures for handling small-molecule library compounds in screening contexts. Adapt to your assay and consult the CoA/SDS for this SKU.
Preparing a DMSO stock (general)
Allow vial to equilibrate to room temperature in a desiccator. Weigh the required amount rapidly.
Add anhydrous DMSO to prepare a 10 mM or 50 mM stock. Vortex and, if needed, sonicate briefly. Filter through 0.22 μm PTFE if particulate persists (if compatible).
Aliquot into low-bind tubes; flush headspace with inert gas if oxidation is a concern (structure-dependent).
Plate preparation for HTS/HCS (general)
Use acoustic or pin-tool transfer to dispense nanoliter volumes; backfill with assay buffer to reach target final concentration while keeping DMSO ≤0.5–1.0% v/v.
Include vehicle controls, detergent controls (e.g., 0.01–0.05% Tween-20) to detect aggregation, and orthogonal readouts when feasible.
Stability checks (general)
Confirm stability over the assay window (light/pH/temperature). Re-prepare working solutions if activity drifts.
These steps are general guidance only and are not validated specifically for AR-M1000390.
Biological Roles
Item-specific biological function, targets, and pathways are not provided for this Moligand library member.
Item-specific data
Target(s), pathway involvement, and mechanism: Not specified for this item; refer to CoA/Spec Sheet or associated screening documentation.
General guidance for library compounds
Use in primary/secondary assays to probe biochemical pathways, validate target engagement, or develop preliminary structure–activity relationships (SAR) once hits are observed.
Complement activity data with orthogonal assays (e.g., biophysical binding, thermal shift) to confirm on-target effects and identify potential assay artifacts (fluorescence interference, redox cycling, aggregation).
If moving toward cellular studies, evaluate permeability, efflux liability, and cytotoxicity of the vehicle and compound using standard counterscreens.
Data management
Maintain clear linkage between SKU, any external IDs (e.g., CID), and your internal tracking to ensure reproducibility when retesting or ordering follow-up analogs.
No medical or clinical claims are made. This product is supplied strictly for research use only.
Buffer Applications
Not typically applicable. As a small-molecule library compound with undisclosed structure, it is not a buffering agent and does not define a useful conjugate acid/base pair for buffer preparation.
Practical note (general)
Working solutions are commonly prepared by diluting DMSO stocks into assay buffers (e.g., PBS, HEPES, Tris) while keeping final DMSO ≤0.5–1.0% v/v to minimize biological interference.
Verify compound stability in the selected buffer (pH, ionic strength) once structural information is available.
Green Alternatives
Given the absence of a disclosed structure, “green” considerations focus on solvent and process choices surrounding the use of this small-molecule library compound rather than on the compound itself.
Solvent choices (general guidance)
Prefer water-based assay buffers with minimal co-solvent when solubility permits.
Use DMSO judiciously; keep final assay concentration at or below 0.5–1.0% v/v to reduce environmental burden and biological interference.
Where feasible, consider bio-based solvents (e.g., 2-propanol of biogenic origin) for cleaning and intermediate handling.
Operational practices
Employ miniaturized formats (384/1536-well) to reduce solvent and compound usage in screening.
Implement closed solvent reservoirs and vapor-tight dispensing to limit emissions when using volatile organics (e.g., acetonitrile).
Consolidate waste by segregating halogenated vs non-halogenated streams to enable compliant disposal and potential recycling.
Trade-offs
DMSO alternatives (e.g., PEG-400, glycoethers) may improve safety but can affect assay performance and viscosity; validate thoroughly.
Aqueous-only systems are greener but may not dissolve lipophilic chemotypes; may require co-solvent or surfactant additives.
For compound-specific green metrics (e.g., degradability, EHS profile), the SDS/CoA must be consulted once structural information is available.
Pharmaceutical Uses
Not applicable for this listing. This Moligand library compound is provided for research use only and is not intended for human or veterinary use, diagnostic procedures, or as an excipient in approved formulations.
General context (non-clinical)
Library compounds may serve as tool molecules in preclinical research, hit identification, and SAR development. Any translation to formulation studies would require comprehensive characterization, safety evaluation, and regulatory assessment not provided here.
Item-specific regulatory status
Pharmacopeial status, GMP compliance, and excipient qualifications are not specified for this item; refer to CoA/Spec Sheet if applicable.
Physical Properties
Item-specific physicochemical parameters are not supplied in the Product Data for this Moligand library member.
Item-specific values
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
Melting/Boiling Point: Not specified for this item; refer to CoA/Spec Sheet.
Density/Refractive Index: Not specified for this item; refer to CoA/Spec Sheet.
Solubility (water/organic): Not specified for this item; refer to CoA/Spec Sheet.
logP/logD, pKa: Not specified for this item; refer to CoA/Spec Sheet.
General guidance for small-molecule library compounds (literature/practice)
Many drug-like compounds are prepared and stored as DMSO stock solutions (e.g., 10–50 mM) due to broad solubilizing power.
Alternative solvents commonly evaluated include DMF, acetonitrile, ethanol, or buffered aqueous media with co-solvent (literature/general guidance).
Compounds bearing multiple H-bond donors/acceptors or ionic groups may show improved water miscibility; highly lipophilic scaffolds may require gentle warming or sonication in DMSO/DMF (general practice).
Practical note
Confirm actual solubility and stability of this specific item from the CoA/SDS or by a small-scale solubility screen before preparing assay stocks.
Quality and Grades
Item-specific information
Grade/Purity: Moligand™ (library designation as provided in Product Data). Specific purity, residual solvent content, and analytical limits are not specified for this item; refer to CoA/Spec Sheet.
Appearance: Not specified for this item; refer to CoA/Spec Sheet.
What Moligand™ typically implies (general description; not item-specific specs)
Inclusion in a small-molecule/compound library intended for discovery research, screening, and ligand identification workflows.
Emphasis on batch identity and consistency suitable for hit-finding and SAR exploration, often supported by analytical characterization such as LC/MS and/or NMR in the accompanying documentation (consult CoA for this item).
Considerations for screening-grade compounds (general guidance)
For HTS/HCS: low particulate burden and reliable solubility in DMSO are practical priorities.
For biophysical assays (SPR, MST, DSF): assess purity, aggregate behavior, and fluorescence interference; request full analytical data when needed.
For cellular assays: check for residual reactive impurities and confirm endotoxin is not relevant (typically not specified for small molecules).
Recommended verifications before use
Confirm purity and identity from the CoA (e.g., LC purity, MS match).
Verify salt form, hydrate/solvate state, and counterions, as these impact solubility and dosing.
If critical to your workflow (e.g., quantitative SAR), consider in-house orthogonal QC (LC-HRMS, qNMR) after receipt.
Reaction and Applications
This Moligand library compound is intended primarily as a small-molecule research tool (ligand/hit candidate) rather than a synthetic reagent. Reaction chemistry guidance is therefore provided only at a general level.
Research applications (general for library members)
Target screening: biochemical enzyme inhibition/activation assays, receptor binding, and biophysical methods (SPR, MST, DSF) to assess ligandability.
Cellular assays: phenotypic screens, reporter assays, and pathway modulation studies, after verifying solubility and cytotoxicity of vehicle.
Chemoinformatics/SAR: as a node in virtual or experimental SAR matrices; corroborate structure and purity via CoA.
Practical tips (general)
Prepare concentrated DMSO stocks (e.g., 10 mM), verify clarity after serial dilutions in assay buffer, and monitor for colloidal aggregation (detergent test, light scattering) that may yield false positives.
Evaluate redox reactivity or covalency if functional groups suggest such behavior (consult structure once available); include counter-screens to deconvolute assay artifacts.
Track compound stability under assay conditions (light, pH, temperature); re-assess activity with freshly prepared aliquots if signal drifts.
Not typically applicable
Named organic reactions, reagents, and stoichiometric synthetic uses cannot be specified without structure. If planning derivatization or analog synthesis, please obtain the structural file (SMILES/SDF) and CoA first.
Reaction Conditions
Not applicable. This product is positioned as a small-molecule library compound for screening rather than as a reagent for preparative organic synthesis. Without a disclosed structure, typical reaction solvents, catalysts, temperatures, and yields cannot be responsibly recommended.
General note
If you require reaction-condition guidance for derivatization or scaffold modification, please obtain the structural file (SMILES/SDF) and consult primary literature relevant to the identified functional groups.
Safety and Handling
Hazard classification details are not provided in the Product Data for this library compound. Handle conservatively as a chemical of unknown hazards.
Item-specific safety fields
GHS Classification: Not specified for this item; refer to SDS.
Signal Word / H-Statements / Pictograms: Not specified for this item; refer to SDS.
General laboratory precautions (defer to SDS for authoritative guidance)
Wear appropriate PPE: lab coat, safety glasses, and nitrile gloves. Use in a fume hood to avoid inhalation of dusts or solvent vapors.
Avoid contact with skin and eyes; prevent ingestion and inhalation. Wash thoroughly after handling.
In case of exposure: rinse eyes/skin with water for at least 15 minutes; seek medical attention if irritation persists. If inhaled, move to fresh air; if ingested, rinse mouth and seek medical advice. Follow institutional protocols.
Storage incompatibilities and general handling
Keep away from strong oxidizers and incompatible reagents until composition is confirmed by CoA/SDS.
Prepare solutions using dry, high-purity solvents to minimize hydrolysis/oxidation risk for sensitive chemotypes (general precaution).
Spill and waste
Absorb small spills with inert material and dispose according to local regulations. Collect waste in properly labeled containers pending hazard confirmation.
Always consult the official SDS for this exact SKU before use.
Solvent Selection
Without a disclosed structure, solvent recommendations are provided as general guidance for small-molecule library members used in screening and assays.
Practical starting points (general/literature)
DMSO: primary solvent for stock solutions (e.g., 10–50 mM) owing to broad solubilizing capacity and chemical compatibility across assays.
DMF or acetonitrile: alternatives for poorly soluble scaffolds; can be back-diluted into assay buffers at ≤1–2% v/v.
Ethanol: useful for some lipophilic compounds; check cellular tolerance if used in cell-based assays.
Aqueous buffers with co-solvent (DMSO, ACN, ethanol at 0.1–1% v/v): for direct assay use when compound solubility permits.
ACN: miscible; low viscosity; watch volatility in automated dispensing.
Ethanol: biocompatible at low %; limited for highly hydrophobic chemotypes.
Confirm item-specific solvent compatibility from the CoA/SDS where available.
Storage and Reconstitution
Item-specific storage and shipping
Storage Conditions: Room temperature (as provided in Product Data).
Shipped In: Not specified for this item; refer to CoA/Spec Sheet.
Solid material handling (general)
Store tightly closed in original container, protected from moisture and excess light. Use a desiccator if humidity is high.
For long-term archiving of solids, consider cool, dry storage even if room temperature is acceptable, to mitigate slow degradation (general practice).
Reconstitution into assay-ready stocks (general)
Prepare an anhydrous DMSO stock (e.g., 10–50 mM). Vortex and, if necessary, gently warm (≤40°C) or sonicate briefly to dissolve. Avoid prolonged heating.
Aliquot into single-use portions to minimize freeze–thaw and air exposure; store aliquots at −20°C or −80°C for extended periods when compatible with the compound (structure-dependent; verify via CoA or pilot stability tests).
Thaw at room temperature, vortex to homogeneity, and inspect for precipitation before use. Discard if discoloration or precipitation persists.
Stability caveat
Exact shelf life, hygroscopicity, and light sensitivity are not specified for this item; refer to CoA/Spec Sheet. Validate stability under your specific storage and assay conditions prior to critical experiments.
Structure and Identity
This entry is part of Aladdin’s Moligand small-molecule library. Detailed structural identifiers are not provided in the Product Data for this specific SKU.
Item-specific identifiers (from Product Data)
SKU: A607733 (catalog identifier)
Product Name: AR-M1000390 (library compound code)
CAS: A607733 (not a standard CAS format; catalog internal reference)
CID: 9841259 (literature/database identifier; structure not confirmed here)
InChIKey: 339958 (not in standard 27-character format; structure not confirmed here)
SMILES: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
Notes on structure description
A precise 2D/3D structural description cannot be provided without a verified SMILES/InChI.
If you require exact structural features (functional groups, ring systems, stereochemistry), please request the compound’s CoA/Spec Sheet or an SD file from our technical support.
Data integrity reminder
Where external identifiers (e.g., CID) are listed without a matching structure on this page, treat them as pointers for literature lookup only. Verify against the official CoA/SDS before experimental use.
Synthetic Utility
Specific synthetic roles cannot be defined without a disclosed structure. Consequently, functional-group reactivity, protecting-group strategies, and named-reaction participation for this molecule are not provided.
If synthetic derivatization is intended
Obtain the SMILES/SDF and CoA to confirm functional groups, oxidation state, and potential liabilities (e.g., acid-labile moieties, redox-active centers).
Perform small-scale compatibility tests before planning multi-step routes, evaluating stability to common conditions (acids/bases, oxidants/reductants, heat, light).
Consider salt/base form and counterions (if any), as they affect isolation and workup.
Alternative approach
If the objective is SAR expansion rather than use of this exact compound, cheminformatic searches based on the library code or external ID (CID) may identify synthetically tractable analogs.
Target Specificity
Target, epitope, and species reactivity fields apply to biologics (e.g., antibodies) and are not applicable to a small-molecule library compound.
Item-specific target data
Primary biological target(s): Not specified for this item; refer to CoA/Spec Sheet.
No clone, isotype, or antigen details are associated with this SKU.
자주 묻는 질문
What are the CAS number, molecular formula and molecular weight?
The CAS Number is A607733. InChIKey SMUGAZNLKPFBSB-UHFFFAOYSA-N.
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
We use cookies to ensure the website functions properly and, where permitted, to improve your experience. You can manage your preferences at any time in Settings. Learn more in our Cookie Policy.
Shall we send you a message when we have discounts available?
Remind me later
Thank you! Please check your email inbox to confirm.
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
