Arbidol HCl - 10mM in DMSO , CAS No.131707-23-8

CAS: 131707-23-8 Cat. No.: A407753 분자식: C₂₂H₂₅BrN₂O₃S.HCl 분자량: 513.88 EC 번호: 680-680-9

GRADE & PURITY 10mM in DMSO

Synonyms

Umifenovir hydrochloride, Arbidol hydrochloride | 6-​bromo-​4-​[(dimethylamino)​methyl]​-​5-​hydroxy-​1-​methyl-​2-​[(phenylthio)​methyl]​-1H-​indole-​3-​carboxylic acid ethyl ester, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Arbidol HCl Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
In vitro

Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively.

In vivo

Cell Data

cell lines：U87MG

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

동의어

Umifenovir hydrochloride, Arbidol hydrochloride | 6-​bromo-​4-​[(dimethylamino)​methyl]​-​5-​hydroxy-​1-​methyl-​2-​[(phenylthio)​methyl]​-1H-​indole-​3-​carboxylic acid ethyl ester, hydrochloride (1:1)

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

이성체 SMILES

CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl

WGK 독일

3

분자량

513.88

Reaxy-Rn

5469513

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5469513&ln=

화학 및 물리적 특성

• 녹는점(°C): 133-137°C

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 131707-23-8, the molecular formula is C22H26BrClN2O3S, and the molecular weight is 513.88 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.