ARI-1 is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 ( ROR1 ) inhibitor. ARI-1 effectively inhibits aberrant ROR1 expression, which is associated with the development of non-small cell lung cancer (NSCLC) and EGFR-TKI-induced drug resistance. ARI-1 binds to the extracellular Frizzled domain of ROR1 and regulates PI3K / AKT / mTOR signaling in a ROR1-dependent manner. ARI-1 potently inhibits NSCLC cell proliferation and migration and has antitumor activity in vivo.

Specifications

사양 및 순도

≥99%

보관 조건

Store at 2-8°C

배송

Wet ice

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작업 유형

ACTIVATOR

순수함

≥99%

이름과 식별자

분자량	374.38

Documentation

📋 Safety Data Sheet (SDS)

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

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ARI-1 - ≥99% , CAS No.A1421463

Why this grade

Storage & shipping

Quality documents

Literature proof

개요