AUT1 - ≥99% , CAS No.1311136-84-1

CAS: 1311136-84-1 Cat. No.: A648897 분자식: C₁₈H₁₉N₃O₄ 분자량: 341.36

등급 & 순도 ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC 50 values of 5.33 and 5.31 μM, respectively. AUT1 can be used for the research of disorders associated with dysfunction of inhibitory feedback in corticolimbic circuits, such as schizophrenia

In Vitro

AUT1 (1.5, 12.5, and 25 μM) modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC 50 s of 5.33 and 5.31 μM, respectively. AUT1 increases whole currents mediated by human Kv3.1b and Kv3.2a channels in a concentration-dependent manner. AUT1 (10 and 30 μM) shifts both the voltage dependence of activation and inactivation of human Kv3.1b and Kv3.2a channels. AUT1 rescues (1 and 10 μM) the fast firing of EGFP-positive cortical interneurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:pEC50: 5.33 μM(Kv3.1b),5.31 μM (Kv3.2a)

사양

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC 50 values of 5.33 and 5.31 μM, respectively. AUT1 can be used for the research of disorders associated with dysfunction of inhibitor

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

MODULATOR

순수함

≥99%

이름과 식별자

분자량

341.36

화학 및 물리적 특성

• 용해성: DMSO : ≥ 250 mg/mL (732.36 mM)