Avanafil - Moligand™, 10mM in DMSO , Phosphodiesterase 5A inhibitor, CAS No.330784-47-9, Phosphodiesterase 5A inhibitor

CAS: 330784-47-9 Cat. No.: A408935 분자식: C₂₃H₂₆ClN₇O₃ 분자량: 483.95 EC 번호: 841-424-3

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Avanafil is a highly selectivePDE5inhibitor withIC50of 5.2 nM, >121-fold selectivity over other PDEs.
In vitro

In vivo

Avanafil (i.v.) potentiates penile tumescence with ED200% of 37.5 μg/kg in dogs. Furthermore, intraduodenal treatment of Avanafil potentiates pelvic nerve stimulation induced changes in intracavernous pressure and duration. The cavernous injection of avanafil (1 μM) in T2DM rats results in partial improvement in erectile responses.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

5-Pyrimidinecarboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Phosphodiesterase 5A inhibitor

제품 특성

ALogP

2.6

이름과 식별자

이성체 SMILES

COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCC[C@H]4CO)Cl

분자량

483.95

Reaxy-Rn

38205117

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38205117&ln=

관련 대상(인간)

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase (25 Activities)

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 74 mg/mL (200.31 mM); Water: Insoluble; Ethanol: Insoluble
• 특정 회전[α]: -62.0 to -72.0 deg (C=1, methanol)
• 녹는점(°C): 165℃

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 330784-47-9, the molecular formula is C23H26ClN7O3, and the molecular weight is 483.95 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.