AZD0095 - ≥99% , CAS No.2750001-23-9

CAS: 2750001-23-9 Cat. No.: A651280 분자식: C₂₇H₃₂N₈O₂ 분자량: 500.60

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

AZD0095 is a selective and orally active MCT4 inhibitor ( IC 50 : 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib

In Vitro

AZD0095 (0-50 µM) inhibits cell proliferation in NCI-H358 cells (high expression of MCT4), with an IC 50 of 26 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD0095 (100 mg/kg, p.o. bid) together with Cediranib (3 mg/kg, p.o.) reduces tumor growth in a murine NCI-H358 xenograft . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Murine NCI-H358 xenograft Dosage: 100 mg/kg together with Cediranib (3 mg/kg) Administration: Oral administration (p.o.) Result: Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone.

Form:Solid

IC50& Target:MCT4 1.3 nM (IC 50 )

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

AZD0095 is a selective and orally active MCT4 inhibitor ( IC 50 : 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib ( HY-10205 ).

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• 분자량: 500.60