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· · COA & SDS 모든 제품에 대한 사용 가능 · 주식 상품에 대한 같은 날 배송 AZD1979 - ≥98% , CAS No.1254035-84-1
Synonyms
AZD 1979 [WHO-DD] | BDBM50159343 | DTXSID001106011 | (3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone | [5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-
Shipped In
Ice chest + Ice pads
개요 AZD1979 is a Melanin-concentrating hormone receptor 1 ( MCHr1 ) antagonist with an IC 50 of ~12 nM.
In Vivo
In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: ~12 nM (MCHr1)
사양 동의어
AZD 1979 [WHO-DD] | BDBM50159343 | DTXSID001106011 | (3-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone | [5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-
생화학 및 생리적 메커니즘
AZD1979 is a Melanin-concentrating hormone receptor 1 ( MCHr1 ) antagonist with an IC 50 of ~12 nM.
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
이름과 식별자 정식 스마일
COC1=CC=C(C=C1)C2=NN=C(O2)C(=O)N3CC(C3)OC4=CC=C(C=C4)CN5CC6(C5)COC6
IUPAC Name
[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]methanone
InChIKey
BKKPIQPFRAPEAY-UHFFFAOYSA-N
INCHI
1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3
이성체 SMILES
COC1=CC=C(C=C1)C2=NN=C(O2)C(=O)N3CC(C3)OC4=CC=C(C=C4)CN5CC6(C5)COC6
MeSH 용어
(3-(4-(2-oxa-6-azaspiro(3.3)heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone;AZD1979
고급 데이터 Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids 분류 Benzene and substituted derivatives Subclass Phenylmethylamines Intermediate Tree Nodes Not available Direct Parent Phenylmethylamines Alternative Parents Phenoxy compounds 2-heteroaryl carboxamides Methoxybenzenes Benzylamines Anisoles Alkyl aryl ethers Aralkylamines Tertiary carboxylic acid amides 1,3,4-oxadiazoles Heteroaromatic compounds Trialkylamines Oxetanes Amino acids and derivatives Azetidines Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Anisole - Benzylamine - Phenol ether - Phenylmethylamine - Methoxybenzene - Phenoxy compound - 2-heteroaryl carboxamide - Aralkylamine - Alkyl aryl ether - Heteroaromatic compound - Azole - 1,3,4-oxadiazole - Oxadiazole - Tertiary carboxylic acid amide - Azetidine - Carboxamide group - Tertiary aliphatic amine - Oxetane - Amino acid or derivatives - Tertiary amine - Ether - Dialkyl ether - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Oxacycle - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Amine - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound 설명 This compound belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 용해성 DMSO : 33.33 mg/mL (72.06 mM; ultrasonic and warming and heat to 60°C) 분자량 462.500 g/mol XLogP3 2.000 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 7 Exact Mass 462.19 Da Monoisotopic Mass 462.19 Da Topological Polar Surface Area 90.200 Ų Heavy Atom Count 34 Formal Charge 0 Complexity 706.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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