Balixafortide TFA - Moligand™, ≥98% , CAS No.1051366-32-5(free base)

CAS: 1051366-32-5(free base) Cat. No.: B658810 분자식: C₈₄H₁₁₈N₂₄O₂₁S₂(free base) 분자량: 1864.11(free base)

GRADE & PURITY Moligand™, ≥98%

Synonyms

POL6326 TFA

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Appearance:Solid

IC50& Target:CXCR4 <10 nM (IC 50 )

In Vitro:Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Namalwa (IC 50 < 200 nM) and Jurkat (IC 50 < 400 nM). Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC 50 < 20 nM), Namalwa and Ju

In Vivo:Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability. MCE has not independently confirmed the accuracy of the

Biological Activity:Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC 50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7 . Balixafortide TFA blocks β-arre

Specifications

동의어

POL6326 TFA

사양 및 순도

Moligand™, ≥98%

보관 조건

Protected from light,Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

ANTAGONIST

순수함

≥98%

이름과 식별자

분자량

1864.11(free base)

화학 및 물리적 특성

• 용해성: H2O : 100 mg/mL (50.55 mM; Need ultrasonic) DMSO : 100 mg/mL (50.55 mM; Need ultrasonic)
• 감도: Light sensitive；Moisture sensitive