BAY-298 - ≥99% , CAS No.2471978-97-7

CAS: 2471978-97-7 Cat. No.: B650354 분자식: C₂₇H₂₁ClFN₃O₂ 분자량: 473.93

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels

In Vivo

BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus . BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t 1/2 s of 31 hours and 33 hours for iv and po. And the C max s are 0.28 kg/L and 0.066 kg/L for iv and po . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Intact female rats Dosage: 4.5, 9, 18, 36, 72 mg/kg Administration: Oral; for 8 days Result: Dosedependently lowered serum estradiol levels in proestrus. Animal Model: Female and male Wistar rats Dosage: 0.5 mg/kg of iv or 2 mg/kg of po Administration: Iv or po Result: Has t 1/2 s of 31 hours and 33 hours for iv and po. And the C max s are 0.28 kg/L and 0.066 kg/L for iv and po.

Form:Solid

IC50& Target:IC50: 185 nM (hLH), 46nM (rLH) and 78 nM (cLH)

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥99%

이름과 식별자

• 정식 스마일: O=C(N1[C@@H](C2=CC=C(Cl)C=C2)C3=C(N=CC=C3)CC1)NC4=CC=C(OC5=CC=C(F)C=C5)C=C4
• 분자량: 473.93

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (211.00 mM; Need ultrasonic)