BBIQ - ≥97% , CAS No.1229024-57-0

CAS: 1229024-57-0 Cat. No.: B647614 분자식: C₂₁H₂₂N₄ 분자량: 330.43

GRADE & PURITY ≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of  59.1 nM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses

In Vitro

BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice treated with Chloroquine (CQ) alone, parasite ( P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ + CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ + CQ which reveals the generation of strong Th1 immune response in mice against the infection . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TLR7 59.1 nM (EC 50 , Human TLR7)

Specifications

사양 및 순도

≥97%

생화학 및 생리적 메커니즘

BBIQ is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC 50 of u202f59.1u202fnM for human TLR7 . BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

AGONIST

순수함

≥97%

이름과 식별자

• 분자량: 330.43

화학 및 물리적 특성

• 용해성: DMSO : 16.67 mg/mL (50.45 mM; ultrasonic and warming and heat to 60°C)