BCI hydrochloride - 10mM in DMSO , CAS No.95130-23-7

CAS: 95130-23-7 Cat. No.: B656630 분자식: C₂₂H₂₄ClNO 분자량: 353.89 PubChem CID: 69670465

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BCI ((E)-BCI) hydrochloride is a DUSP6 ( dual specificity phosphatase 6 ) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research

In Vitro

BCI (100 ng/mL; 24 h) downregulats the expression of DUSP6 in RAW264.7 macrophage cells. BCI (0-1 nM; 24 h) inhibits the expression of IL-1β and IL-6 in lipopolysaccharide- (LPS-) activated macrophages. BCI (0-4 nM; 24 h) decreases ROS production and activates the Nrf2 Pathway in LPS-activated macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 macrophage cells Concentration: 100 ng/mL Incubation Time: 24 hours Result: Showed DUSP6 protein downregulation. RT-PCRCell Line: RAW264.7 macrophage cells Concentration: 0-1 nM Incubation Time: 24 hours Result: Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.

IC50& Target:DUSP6

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BCI ((E)-BCI) hydrochloride is a DUSP6 ( dual specificity phosphatase 6 ) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

이성체 SMILES

C1CCC(CC1)NC\2C3=CC=CC=C3C(=O)/C2=C/C4=CC=CC=C4.Cl

WGK 독일

3

PubChem CID

69670465

분자량

353.89