BF 227 - 10mM in DMSO , CAS No.845647-80-5

CAS: 845647-80-5 Cat. No.: B654479 분자식: C₁₆H₁₆FN₃O₂S 분자량: 333.38 PubChem CID: 10404577

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BF 227 is a candidate for an amyloid imaging probe for PET, with a K i of 4.3 nM for Aβ1-42 fibrils .

In Vitro

BF-227 has a high binding affinity for Aβ1-42 fibrils. The K i value for Aβ1-42 fibrils in competitive binding assay using [ 125 I]BF-180 is 4.3±1.3 nM in BF-227 (K d value of [ 125 I]BF-180: 10.8±1.5 nM). [ 11 C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Ki: 4.3 nM (Aβ1-42)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BF 227 is a candidate for an amyloid imaging probe for PET, with a K i of 4.3 nM for Aβ1-42 fibrils .

보관 조건

Argon charged,Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: CN(C)C1=NC=C(S1)/C=C/C2=NC3=C(O2)C=C(C=C3)OCCF
• PubChem CID: 10404577
• 분자량: 333.38