BI-4924 - 10mM in DMSO , CAS No.2244452-09-1

CAS: 2244452-09-1 Cat. No.: B654559 분자식: C₂₁H₂₀Cl₂N₂O₆S 분자량: 499.36

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase ( PHGDH ) inhibitor ( IC 50 =3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC 50 of 2200 nM at 72 h

In Vitro

BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD + )-competitive PHGDH inhibitor. BI-4924 shows high selectivity against the majority of other dehydrogenase targets. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PHGDH

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase ( PHGDH ) inhibitor ( IC 50 =3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis wi

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 분자량: 499.36