BI 99179 - 10mM in DMSO , CAS No.1291779-76-4

CAS: 1291779-76-4 Cat. No.: B655815 분자식: C₂₃H₂₅N₃O₃ 분자량: 391.46 EC 번호: 867-055-8 PubChem CID: 51346964

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BI 99179 is a potent and selective type I fatty acid synthase ( FAS ) inhibitor with an IC 50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats

In Vitro

BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC 50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM. BI 99179 (BI-99179; 1, 2, and 4 µM) shows antiproliferative efficacy in human glioma GAMG cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Human glioma GAMG cells Concentration: 1, 2, 4 µM Incubation Time: 96 to 120 hours Result: The optimal palmitate concentration for GAMG cell line was 4 µM.

In Vivo

BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t 1/2 ) of 3.0 h . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 79 nM (FASN)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BI 99179 is a potent and selective type I fatty acid synthase ( FAS ) inhibitor with an IC 50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

이성체 SMILES

CCC(=O)N[C@H]1CC[C@H](C1)C(=O)N(C)C2=CC=C(C=C2)C3=NC4=CC=CC=C4O3

PubChem CID

51346964

분자량

391.46