BML-190 - 10mM in DMSO , CAS No.2854-32-2

CAS: 2854-32-2 Cat. No.: B408769 분자식: C₂₃H₂₃ClN₂O₄ 분자량: 426.89

GRADE & PURITY 10mM in DMSO

Synonyms

IMMA | Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

BML-190 (IMMA) is a selectivecannabinoid CB2 receptorinverse agonist withKiof 435 nM, with 50-fold selectivity over CB1 receptor.
In vitro

BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction.

In vivo

Cell Data

cell lines：

Concentrations：0 μM -100 μM

Incubation Time：20 hours–24 hours

Powder Purity:≥99%

Specifications

동의어

IMMA | Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with K_i of 435 nM, with 50-fold selectivity over CB1 receptor.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

AGONIST

이름과 식별자

• 이성체 SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)N4CCOCC4
• 분자량: 426.89
• Reaxy-Rn: 1230853
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1230853&ln=

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 69 mg/mL (199.15 mM); Ethanol: 9 mg/mL warmed with 50ºC Water: bath (25.97 mM); Water: Insoluble