Bocidelpar - Moligand™,≥98% , CAS No.2095128-20-2

CAS: 2095128-20-2 Cat. No.: B648929 분자식: C₂₅H₂₇F₃N₂O₃ 분자량: 460.49 PubChem CID: 126752383

등급 & 순도 Moligand™, ≥98%

Synonyms

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Bocidelpar is a selective PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD).

사양

동의어

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

사양 및 순도

Moligand™,≥98%

생화학 및 생리적 메커니즘

Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta ( PPAR-δ ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b).

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

MODULATOR

순수함

≥98%

이름과 식별자

이성체 SMILES

CC1=CN=C(N1CC2=CC=CC=C2OCCC[C@@H](C)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F

PubChem CID

126752383

분자량

460.49

화학 및 물리적 특성

• 용해성: DMSO : 250 mg/mL (542.90 mM; Need ultrasonic)
• 분자량: 460.500 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 460.197 Da
• Monoisotopic Mass: 460.197 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 610.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1