BPN-15606 - 10mM in DMSO , CAS No.1914989-49-3

CAS: 1914989-49-3 Cat. No.: B654910 분자식: C₂₃H₂₃FN₆O 분자량: 418.47 PubChem CID: 121305852

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance

In Vivo

BPN-15606 (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice . BPN-15606 (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of Aβ42 and Aβ40 levels in rats . BPN-15606 (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following the single dose administration and lasted for ≥24 hours in C57BL/6 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:γ-secretase

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervo

보관 조건

Argon charged,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

MODULATOR

이름과 식별자

• PubChem CID: 121305852
• MeSH 용어: BPN-15606;N-(1-(4-fluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine
• 분자량: 418.47