Broflanilide - 10mM in DMSO , CAS No.1207727-04-5

CAS: 1207727-04-5 Cat. No.: B654863 분자식: C₂₅H₁₄BrF₁₁N₂O₂ 분자량: 663.28 EC 번호: 690-677-4 PubChem CID: 53341374

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

In Vitro

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABA A α1β2γ2 receptor, the mammalian GABA A α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC 50 s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC 50 s, 0.706, 0.149 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ANTAGONIST

이름과 식별자

• 이성체 SMILES: CN(C1=CC=CC(=C1F)C(=O)NC2=C(C=C(C=C2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)C3=CC=CC=C3
• PubChem CID: 53341374
• 분자량: 663.28

참고 문헌

1. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665] [10.1002/ps.7415]