BSc3094 - ≥98% , CAS No.946857-84-7

CAS: 946857-84-7 Cat. No.: B650707 분자식: C₁₇H₁₂N₆O₃S 분자량: 380.38

등급 & 순도 ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD)

In Vivo

BSc3094 (3 mg/kg; i.v.) direct intraventricular administration reduces sarkosyl-insoluble Tau . BSc3094 (0.075~1.5 mM; intraventricular administration) reduces the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70% . BSc3094 reverses the pre-synaptic impairment in organotypic hippocampal slices from pro-aggregant mice, by reversing the pairedpulse depression observed in non-treated pro-aggregant Tau slices after applying a paired-pulse stimulus of the Schaffer collaterals. BSc3094 reverses the increase in Tau phosphorylation levels in rTg4510 mice down to control level. BSc3094 partially reversed the memory deficits in rTg4510 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice Dosage: 3 mg/kg Administration: I.v. Result: Direct intraventricular administration reduced sarkosyl-insoluble Tau. Animal Model: rTg4510 mice Dosage: 0.075~1.5 mM Administration: Intraventricular administration Result: Reduced the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%.

Form:Solid

IC50& Target:Tau aggregation

사양

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

BSc3094 is a Tau aggregation inhibitor. BSc3094 can be used for the research of Alzheimer's disease (AD).

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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순수함

≥98%

이름과 식별자

정식 스마일

O=C(C1=CC=C2N=CNC2=C1)NNC3=NC(C4=CC=C([N+]([O-])=O)C=C4)=CS3

분자량

380.38

화학 및 물리적 특성

• 용해성: DMSO : 33.33 mg/mL (87.62 mM; Need ultrasonic)