BT-13 - 10mM in DMSO , CAS No.924537-98-4

CAS: 924537-98-4 Cat. No.: B655685 분자식: C₂₃H₂₇F₄N₃O₄S 분자량: 517.54 PubChem CID: 46088379

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat

In Vitro

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rats induced by ligation of left L5 and L6 spinal nerves . Dosage: 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. Administration: Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. Result: 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

IC50& Target:GDNF receptor RET

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

AGONIST

이름과 식별자

이성체 SMILES

CCN(CC)S(=O)(=O)C1=CC(=C(C=C1)OC)N2CCN(CC2)C(=O)C3=C(C=C(C=C3)F)C(F)(F)F

PubChem CID

46088379

분자량

517.54