BTD - Moligand™, ≥98%(HPLC) , Activator of TRPC5, CAS No.896684-04-1, Activator of TRPC5

CAS: 896684-04-1 Cat. No.: B288219 분자식: C₂₄H₃₃N₃O₄S 분자량: 459.61 PubChem CID: 46369355

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

동의어

6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide

사양 및 순도

Moligand™, ≥98%(HPLC)

생화학 및 생리적 메커니즘

Selective TRPC5 activator (EC50= 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50= 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

ACTIVATOR

작동 메커니즘

Activator of TRPC5

순수함

≥98%(HPLC)

이름과 식별자

• 정식 스마일: CC1=CC2=C(C=C1)S(=O)(=O)N=C(N2)CCC(=O)NCCCOC34CC5CC(C3)CC(C5)C4
• IUPAC Name: N-[3-(1-adamantyloxy)propyl]-3-(6-methyl-1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-3-yl)propanamide
• InChIKey: YXADKMPRWFBOHW-UHFFFAOYSA-N
• INCHI: 1S/C24H33N3O4S/c1-16-3-4-21-20(9-16)26-22(27-32(21,29)30)5-6-23(28)25-7-2-8-31-24-13-17-10-18(14-24)12-19(11-17)15-24/h3-4,9,17-19H,2,5-8,10-15H2,1H3,(H,25,28)(H,26,27)
• 이성체 SMILES: CC1=CC2=C(C=C1)S(=O)(=O)N=C(N2)CCC(=O)NCCCOC34CC5CC(C3)CC(C5)C4
• PubChem CID: 46369355
• 분자량: 459.61

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Thiadiazines
      • Subclass Benzothiadiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Thiadiazines
• Subclass: Benzothiadiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,2,4-benzothiadiazine-1,1-dioxides
• Alternative Parents: Imidolactams Fatty amides Benzenoids Organosulfonic acids and derivatives Secondary carboxylic acid amides Dialkyl ethers Azacyclic compounds Amidines Organic oxides Hydrocarbon derivatives Carbonyl compounds Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,2,4-benzothiadiazine-1,1-dioxide - Fatty amide - Benzenoid - Imidolactam - Fatty acyl - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Ether - Dialkyl ether - Carboxylic acid derivative - Amidine - Azacycle - Organic oxide - Organic oxygen compound - Amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

TRPC5 Tchem Short transient receptor potential channel 5 (2 Activities)

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 45.96, Max Conc. mM: 100

참고 문헌

1. Hongyang Wang, Bo Zhao, Rui Dong, Ping Wen, Mingjin Fan.  (2024)  Covalent-Organic Framework Nanomaterials: Energy Band Engineering Generating Ultrathin Lubrication Films for Excellent Lubrication.  ACS Applied Materials & Interfaces,      [PMID:39239968] [10.1021/acsami.4c11808]