Bufexamac - Moligand™, 10mM in DMSO , Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6, CAS No.2438-72-4, Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6

CAS: 2438-72-4 Cat. No.: B407941 분자식: C₁₂H₁₇NO₃ 분자량: 223.27 EC 번호: 219-451-1

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

2-(4-butoxyphenyl)-N-hydroxyacetamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
In vitro

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

2-(4-butoxyphenyl)-N-hydroxyacetamide

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of histone deacetylase 10;Inhibitor of histone deacetylase 6

제품 특성

ALogP

1.9

이름과 식별자

이성체 SMILES

CCCCOC1=CC=C(C=C1)CC(=O)NO

RTECS

AK8280000

분자량

223.27

Reaxy-Rn

2646848

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2646848&ln=

관련 대상(인간)

HDAC6 Tclin Histone deacetylase 6 (1 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 (1 Activities)

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 녹는점(°C): 164 °C(dec.)

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2438-72-4, the molecular formula is C12H17NO3, and the molecular weight is 223.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.