Bumetanide - Moligand™, 10mM in DMSO , Sodium-(potassium)-chloride cotransporter 2 inhibitor, CAS No.28395-03-1, Sodium-(potassium)-chloride cotransporter 2 inhibitor

CAS: 28395-03-1 Cat. No.: B407775 분자식: C₁₇H₂₀N₂O₅S 분자량: 364.42 EC 번호: 249-004-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Bumetanide Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respe
In vitro

In vivo

Cell Data

cell lines：MV-4-11, MM.1S, and K562 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

AGONIST, INHIBITOR

작동 메커니즘

Sodium-(potassium)-chloride cotransporter 2 inhibitor

제품 특성

• ALogP: 2.8

이름과 식별자

• 이성체 SMILES: CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
• WGK 독일: 3
• RTECS: DG4910000
• 분자량: 364.42
• Reaxy-Rn: 2185351
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2185351&ln=

관련 대상(인간)

SLC12A1 Tclin Solute carrier family 12 member 1 (1 Activities)

Discover Target: SLC12A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC12A2 Tclin Solute carrier family 12 member 2 (1 Activities)

Discover Target: SLC12A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

참고 문헌

1. Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Gan.  (2022)  Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.  NEUROSCIENCE,      [PMID:36493910] [10.1016/j.neuroscience.2022.11.033]

2. Dao-Lai Zhang, Yu-Jing Sun, Ming-Liang Ma, Yi-jing Wang, Hui Lin, Rui-Rui Li, Zong-Lai Liang, Yuan Gao, Zhao Yang, Dong-Fang He, Amy Lin, Hui Mo, Yu-Jing Lu, Meng-Jing Li, Wei Kong, Ka Young Chung, Fan Yi, Jian-Yuan Li, Ying-Ying Qin, Jingxin Li, Alex R B Thomsen, Alem W Kahsai, Zi-Jiang Chen, Zhi-Gang Xu, Mingyao Liu, Dali Li, Xiao Yu, Jin-Peng Sun.  (2018)  Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.  eLife,      [PMID:29393851] [10.7554/eLife.33432]

3. Yang Yu, Fangyong Wang.  (2026)  Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice.  Frontiers in Immunology,      [PMID:41929507] [10.3389/fimmu.2026.1751436]