BV-6 TFA salt - Moligand™, ≥98% , CAS No.1001600-56-1(freebase)

CAS: 1001600-56-1(freebase) Cat. No.: B413788 분자식: C₇₀H₉₆N₁₀O₈.xCF₃COOH 분자량: 1205.57（free）

GRADE & PURITY Moligand™, ≥98%

Synonyms

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Information

BV-6 is a SMAC mimetic, dualcIAPandXIAPinhibitor.

Targets

cIAP ; XIAP

In vitro

BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.

Cell Research(from reference)

Cell lines：HCC193 and H460 cells 

Concentrations：~30 μM 

Incubation Time：~48 hours 

Specifications

동의어

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

순수함

≥98%

이름과 식별자

Pubchem Sid

488200364

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488200364

정식 스마일

CNC(C)C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC(C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCCCCCCNC(=O)C(NC(=O)C5CCCN5C(=O)C(NC(=O)C(C)NC)C6CCCCC6)C(C7=CC=CC=C7)C8=CC=CC=C8

분자량

1205.57（free）

관련 대상(인간)

XIAP Tchem E3 ubiquitin-protein ligase XIAP (1 Activities)

Discover Target: XIAP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 100 mg/mL (82.94 mM); Water: 100 mg/mL (82.94 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (82.94 mM)