Calmodulin from bovine testes - ≥98%(SDS-PAGE) , CAS No.77107-46-1

CAS: 77107-46-1 Cat. No.: C140110

GRADE & PURITY ≥98%(SDS-PAGE)

Synonyms

CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory. Many proteins use Calmodulin as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered. Calmodulin is supplied as a lyophilized white powder or flocculate from 50 mM NH4HCO3 with 10 μM CaCl2. No preservatives are added. The protein content is analyzed by amino acid assay and is never less than 80 % of weighed substance. The material has been subjected to an acid treatment for minimum 30 min. The protein is derived from a single batch and is homogenous.
Protein calcium binding studies on the regulation of a multitude of different protein targets; Activation of cyclic nucleotide-dependent phosphodiesterase; Co-factor/activator for kinase studies; Studies of edema factor toxin and anthrax bacteria

Specifications

동의어

CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator

사양 및 순도

≥98%(SDS-PAGE)

생화학 및 생리적 메커니즘

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, I

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥98%(SDS-PAGE)

자주 묻는 질문

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by SDS-PAGE. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 77107-46-1.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.