Carbidopa - Moligand™, 10mM in DMSO , Inhibitor of L-Aromatic amino-acid decarboxylase , CAS No.28860-95-9, Inhibitor of L-Aromatic amino-acid decarboxylase

CAS: 28860-95-9 Cat. No.: C408039 분자식: C₁₀H₁₄N₂O₄ 분자량: 226.23 EC 번호: 249-271-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(αS)​-α-​hydrazinyl-​3,​4-​dihydroxy-​α-​methyl-​benzenepropanoic acid

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
In vitro

In vivo

Cell Data

cell lines：Breast cancer cell lines including SW620 colon, A2780 ovarian, HCC1937, Hs578T, MDA-MB-231, MDA-MB-436, and T47D

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

(αS)​-α-​hydrazinyl-​3,​4-​dihydroxy-​α-​methyl-​benzenepropanoic acid

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

보관 조건

Protected from light,Argon charged,Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of L-Aromatic amino-acid decarboxylase

이름과 식별자

• 이성체 SMILES: C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
• WGK 독일: 3
• 대체 CAS: 38821-49-7
• 분자량: 226.23
• Reaxy-Rn: 657532
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=657532&ln=

관련 대상(인간)

DDC Tclin Aromatic-L-amino-acid decarboxylase (0 Activities)

Discover Target: DDC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro

참고 문헌

1. Jin Yuan Zhang, Ying Zhang, Yu Zou, Ze Li Bo Xu, Bo Zhang, Wang Ren.  (2023)  Physicochemically modulated fluorescence-scattering ratiometric sensor for selective and visual detection of levodopa.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38091648] [10.1016/j.saa.2023.123746]

2. Da-Wei Zhou, Meng Yin, Yun Shen, Xiao-Xue Wang, Chen-Yu Wang, Ke-Zheng Chen, Qi Fang, Sheng-Lin Qiao.  (2024)  LDHzyme-assisted high-performance on-site tracking of levodopa pharmacokinetics for Parkinson's disease management.  BIOSENSORS & BIOELECTRONICS,      [PMID:39536419] [10.1016/j.bios.2024.116926]

3. Shanying Han, Tianyu Du, Hui Jiang, Xuemei Wang.  (2016)  Synergistic effect of pyrroloquinoline quinone and graphene nano-interface for facile fabrication of sensitive NADH biosensor.  BIOSENSORS & BIOELECTRONICS,      [PMID:27156055] [10.1016/j.bios.2016.04.092]