Carbimazole - 10mM in DMSO , Thyroid peroxidase inhibitor, CAS No.22232-54-8, Thyroid peroxidase inhibitor

CAS: 22232-54-8 Cat. No.: C408083 분자식: C₇H₁₀N₂O₂S 분자량: 186.23 EC 번호: 244-854-4

GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Carbimazole is an imidazole antithyroid agent.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

작동 메커니즘

Thyroid peroxidase inhibitor

제품 특성

ALogP

0.7

이름과 식별자

이성체 SMILES

CCOC(=O)N1C=CN(C1=S)C

WGK 독일

3

분자량

186.23

Reaxy-Rn

144339

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

화학 및 물리적 특성

• 녹는점(°C): 124 °C