CBA - Moligand™, ≥98%(HPLC) , Channel blocker of TRPM4;Gating inhibitor of TRPM4, CAS No.351424-20-9, Channel blocker of TRPM4;Gating inhibitor of TRPM4

CAS: 351424-20-9 Cat. No.: C288513 분자식: C₁₅H₁₁Cl₂NO₄ 분자량: 340.16

등급 & 순도 Moligand™, ≥98%(HPLC)

Synonyms

4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid | TRPM4-IN-1 | 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid | Compound 5 | TRPM4 inhibitor 5

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

사양

동의어

4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid | TRPM4-IN-1 | 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid | Compound 5 | TRPM4 inhibitor 5

사양 및 순도

Moligand™, ≥98%(HPLC)

생화학 및 생리적 메커니즘

Selective TRPM4 blocker (IC50= 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegenerationin vitro

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

CHANNEL BLOCKER, GATING INHIBITOR

작동 메커니즘

Channel blocker of TRPM4;Gating inhibitor of TRPM4

순수함

≥98%(HPLC)

이름과 식별자

Pubchem Sid

504760710

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504760710

정식 스마일

C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

IUPAC Name

4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid

InChIKey

CVQCJPCMPGKEDH-UHFFFAOYSA-N

INCHI

1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)

이성체 SMILES

C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl

분자량

340.16

Reaxy-Rn

32871543

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32871543&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Acylaminobenzoic acid and derivatives
• Alternative Parents: 4-halobenzoic acids Halobenzoic acids Anilides Benzoic acids Phenoxy compounds Phenol ethers N-arylamides Benzoyl derivatives Alkyl aryl ethers Chlorobenzenes Aryl chlorides Vinylogous amides Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Acylaminobenzoic acid or derivatives - 4-halobenzoic acid or derivatives - Halobenzoic acid or derivatives - 4-halobenzoic acid - Halobenzoic acid - Benzoic acid - Anilide - Phenol ether - Phenoxy compound - N-arylamide - Benzoyl - Chlorobenzene - Alkyl aryl ether - Halobenzene - Aryl chloride - Aryl halide - Vinylogous amide - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organochloride - Organopnictogen compound - Organohalogen compound - Aromatic homomonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 (2 Activities)

Discover Target: TRPM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

작용 메커니즘

화학 및 물리적 특성

• 용해성: Solvent:DMSO, Max Conc. mg/mL: 17.01, Max Conc. mM: 50
• 분자량: 340.200 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 339.007 Da
• Monoisotopic Mass: 339.007 Da
• Topological Polar Surface Area: 75.600 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 407.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 351424-20-9, the molecular formula is C15H11Cl2NO4, and the molecular weight is 340.16 g/mol. InChIKey CVQCJPCMPGKEDH-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.