CDDO-EA - 10mM in DMSO , CAS No.932730-51-3

CAS: 932730-51-3 Cat. No.: C655012 분자식: C₃₃H₄₆N₂O₃ 분자량: 518.73 PubChem CID: 44159258

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

CDDO-EA is an NF-E2 related factor 2/antioxidant response element ( Nrf2/ARE ) activator.

In Vitro

CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Nrf2/ARE

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

CDDO-EA is an NF-E2 related factor 2/antioxidant response element ( Nrf2/ARE ) activator.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ACTIVATOR

이름과 식별자

이성체 SMILES

CCNC(=O)[C@@]12CC[C@@]3([C@@H]([C@@H]1CC(CC2)(C)C)C(=O)C=C4[C@]3(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)C

PubChem CID

44159258

분자량

518.73