Cinacalcet HCl - ≥99% , Calcium sensing receptor positive allosteric modulator, CAS No.364782-34-3, Calcium sensing receptor positive allosteric modulator

Name: Cinacalcet HCl - ≥99% , Calcium sensing receptor positive allosteric modulator, CAS No.364782-34-3, Calcium sensing receptor positive allosteric modulator
SKU: C129866
Availability: InStock

CAS: 364782-34-3 Cat. No.: C129866 분자식: C₂₂H₂₂F₃N·HCl 분자량: 393.87 EC 번호: 620-490-5 PubChem CID: 156418

COA

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Cinacalcet HCl - ≥99% CAS No(364782-34-3) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥99%

Synonyms

1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride | CAS-364782-34-3 | CINACALCET HYDROCHLORIDE [USP-RS] | MLS006010213 | Z1198150431 | DTXSID3046792 | NPS-1493 | CNC-HCl | N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(t

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 자주 묻는 질문과 기사 솔루션 계산기 리뷰

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.
An allosteric activator of CaSR

Specifications

동의어

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.Ca 2+ -sensing receptor agonist\xa0that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic acti

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

POSITIVE ALLOSTERIC MODULATOR

작동 메커니즘

Calcium sensing receptor positive allosteric modulator

참고

Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥99%

이름과 식별자

Pubchem Sid

504757415

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504757415

정식 스마일

CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

IUPAC Name

N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride

InChIKey

QANQWUQOEJZMLL-PKLMIRHRSA-N

INCHI

1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

이성체 SMILES

C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

PubChem CID

156418

분자량

393.87

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 분류 Naphthalenes

Kingdom	Organic compounds
Superclass	Benzenoids
분류	Naphthalenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Naphthalenes
Alternative Parents	Trifluoromethylbenzenes Phenylpropylamines Aralkylamines Dialkylamines Organopnictogen compounds Organofluorides Hydrochlorides Hydrocarbon derivatives Alkyl fluorides
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Trifluoromethylbenzene - Naphthalene - Phenylpropylamine - Aralkylamine - Monocyclic benzene moiety - Secondary aliphatic amine - Secondary amine - Alkyl fluoride - Hydrochloride - Organonitrogen compound - Organofluoride - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Amine - Alkyl halide - Aromatic homopolycyclic compound
설명	This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
External Descriptors	hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

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리뷰

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Lot Number	Certificate Type	날짜	항목
F2216127	Certificate of Analysis	Dec 12, 2025	C129866
F2216128	Certificate of Analysis	Dec 12, 2025	C129866
F2216130	Certificate of Analysis	Dec 12, 2025	C129866
C1816074	Certificate of Analysis	May 12, 2025	C129866
E1529069	Certificate of Analysis	Sep 05, 2024	C129866
G1825034	Certificate of Analysis	Dec 14, 2023	C129866
C1816075	Certificate of Analysis	Aug 07, 2023	C129866
D2224008	Certificate of Analysis	Feb 28, 2022	C129866
D2224010	Certificate of Analysis	Feb 28, 2022	C129866

용해성	Soluble in water (1 mg/ml at 25 °C), DMSO (79 mg/ml at 25 °C), ethanol (33 mg/ml at 25 °C), and methanol.
분자량	393.900 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	393.147 Da
Monoisotopic Mass	393.147 Da
Topological Polar Surface Area	12.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	422.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2