Clindamycin HCl - 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.21462-39-5, Bacterial 70S ribosome inhibitor

CAS: 21462-39-5 Cat. No.: C409273 Molecular Weight: 461.44 EC Number: 244-398-6 PubChem CID: 16051951

GRADE & PURITY 10mM in DMSO

Synonyms

(L-​threo-​α-​D-​galacto-​Octopyranoside, methyl 7-​chloro-​6,​7,​8-​trideoxy-​6-​[[[(2S,​4R)​-​1-​methyl-​4-​propyl-​2-​pyrrolidinyl]​carbonyl]​amino]​-​1-​thio-​, hydrochloride (1:1))

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Clindamycin HCl Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal , used for the treatment of bacterial infections.
In vitro

Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit.

In vivo

Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. Clindamycin hydrochloride significantly reduces oral malodor from the dogs\' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

(L-​threo-​α-​D-​galacto-​Octopyranoside, methyl 7-​chloro-​6, ​7, ​8-​trideoxy-​6-​[[[(2S, ​4R)​-​1-​methyl-​4-​propyl-​2-​pyrrolidinyl]​carbonyl]​amino]​-​1-​thio-​, hydrochloride (1:1))

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Bacterial 70S ribosome inhibitor

Names and Identifiers

• Isomeric SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
• PubChem CID: 16051951
• Molecular Weight: 461.44

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 73 mg/mL (98.02 mM); Water: Insoluble; Ethanol: Insoluble

References

1. Tong Shao, Xiaoshuang Wang, Rentian Guan, Suyuan Zeng, Rui Li, Min Hong, Qiaoli Yue.  (2023)  Carbonized polymer dots for the sensitive and selective analysis of chlortetracycline based on the aggregation induced emission.  NEW JOURNAL OF CHEMISTRY,  47  (37): (17293-17302).  [PMID:] [10.1039/D3NJ02474A]

2. Wei Xinjie, Luo Xuan, Xu Shuai, Xi Fengna, Zhao Tingting.  (2022)  A Flexible Electrochemiluminescence Sensor Equipped With Vertically Ordered Mesoporous Silica Nanochannel Film for Sensitive Detection of Clindamycin.  Frontiers in Chemistry,      [PMID:35464210] [10.3389/fchem.2022.872582]

3. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2018)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [PMID:] [10.1039/C8AY02284D]