CO23 - ≥98% , CAS No.1370363-74-8

CAS: 1370363-74-8 Cat. No.: C649591 분자식: C₁₉H₁₈I₂N₂O₄ 분자량: 592.17

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier

In Vivo

CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Hypothyroid Wistar rats Dosage: 0.04, 0.8, 2.5, and 5.0 nmol/g Administration: Ip Result: Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.

Form:Solid

IC50& Target:TRα

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

AGONIST

순수함

≥98%

이름과 식별자

• 분자량: 592.17

화학 및 물리적 특성

• 용해성: DMSO : 250 mg/mL (422.18 mM; Need ultrasonic)