Concanamycin A（CMA） - ≥98% , CAS No.80890-47-7

CAS: 80890-47-7 Cat. No.: C102380 분자식: C₄₆H₇₅NO₁₄ 분자량: 866.09 Beilstein Registry Number: 3560277 EC 번호: 620-709-4 PubChem CID: 6438151

GRADE & PURITY ≥98%

Synonyms

DJZCTUVALDDONK-HQMSUKCRSA-N | Folimycin | concanamycin a | HY-N1724 | AKOS024457223 | CHEBI:73167 | Q27140357 | Oxacyclooctadeca-3,5,13,15-tetraen-2-one, 18-((1S,2R,3S)-3-((2R,4R,5S,6R)-4-((4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arbino-hexopyranosyl)oxy)t

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Macrolide type antibiotic, ATPase inhibitor, having antiproliferative, antifungal and antimalarial effects.

Specifications

동의어

DJZCTUVALDDONK-HQMSUKCRSA-N | Folimycin | concanamycin a | HY-N1724 | AKOS024457223 | CHEBI:73167 | Q27140357 | Oxacyclooctadeca-3,5,13,15-tetraen-2-one, 18-((1S,2R,3S)-3-((2R,4R,5S,6R)-4-((4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arbino-hexopyranosyl)oxy)t

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

Potent, selective vacuolar-type H + -ATPase inhibitor (K i = 0.02 nM). Macrolide antibiotic agent. Concanamycin B and C analog. Shows antiproliferative and potent antifungal effects. Shows antimalarial effects in vi

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

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참고

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

순수함

≥98%

이름과 식별자

• Pubchem Sid: 528769955
• 정식 스마일: CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
• IUPAC Name: [(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate
• InChIKey: DJZCTUVALDDONK-HQMSUKCRSA-N
• INCHI: 1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1
• 이성체 SMILES: CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
• WGK 독일: 3
• RTECS: CB9732000
• PubChem CID: 6438151
• UN 번호: 3462
• 분자량: 866.09
• Beilstein: 3560277

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • 분류 Macrolides and analogues

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• 분류: Macrolides and analogues
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Macrolides and analogues
• Alternative Parents: O-glycosyl compounds Monosaccharides Oxanes Carbamate esters Enoate esters Organic carbonic acids and derivatives Secondary alcohols Lactones Hemiacetals Oxacyclic compounds Monocarboxylic acids and derivatives Acetals Dialkyl ethers Organic oxides Hydrocarbon derivatives Carbonyl compounds Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Macrolide - Glycosyl compound - O-glycosyl compound - Monosaccharide - Oxane - Carbamic acid ester - Enoate ester - Alpha,beta-unsaturated carboxylic ester - Carboxylic acid ester - Hemiacetal - Lactone - Carbonic acid derivative - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Carboxylic acid derivative - Acetal - Monocarboxylic acid or derivatives - Dialkyl ether - Ether - Organonitrogen compound - Alcohol - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Carbonyl group - Aliphatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
• External Descriptors: carbamate ester - concanamycin

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(비인간)

Saccharomyces cerevisiae (19171 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Concanamycin A is reported to be soluble in chloroform, methanol, ethanol, acetone, ethyl acetate, and DMSO.Concanamycin A is not soluble in water.
• 감도: Moisture sensitive;Light sensitive
• 분자량: 866.100 g/mol
• XLogP3: 6.000
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 12
• Exact Mass: 865.519 Da
• Monoisotopic Mass: 865.519 Da
• Topological Polar Surface Area: 226.000 Ų
• Heavy Atom Count: 61
• Formal Charge: 0
• Complexity: 1580.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 18
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 5
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 5
• Covalently-Bonded Unit Count: 1

참고 문헌

1. Chen Xiuxiu, Jin Songsong, Du Hong, Liu Zebin, Hou Congcong, Tang Ling, Wang Yuanyuan, Wang Yuxi, Yang Zhaolin, Zhao Tong, Ma Jinying, Zhang Lanjun, Li Meijing, Qi Dongdong, Li Wenlong, Wang Xiaohua, Sun Runze, Moore John P., Liu Yongxiu, Lin Jinxing, Deng Xin.  (2025)  Plasma membrane CYBDOM proteins catalyse apoplastic AsA regeneration and interact with RbohD to activate autophagy and drought tolerance in plants.  Nature Plants,      [PMID:40750697] [10.1038/s41477-025-02057-y]