≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
CPI-455 HCl CPI-455 is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
Targets
KDM5A (Cell-free assay) 10 nM
In vitro
CPI-455 has improved potency against KDM5A while demonstrating ~200-fold selectivity for KDM5A over KDM4C. CPI-455 inhibits KDM5A, KDM5B and KDM5C to similar extents but showed substantially weaker potency toward KDM4C and KDM7B (~200- and 770-fold, respectively) and no measurable inhibition of KDM2B, KDM3B or KDM6A. CPI-455-mediated KDM5 inhibition results in a dose-dependent increase in global H3K4me3 in HeLa cells. CPI-455 specifically alters H3K4 methylation in cells and binds at the demethylase active site.
Cell Research(from reference)
Cell lines：melanoma (M14), breast cancer (SKBR3) and NSCLC (PC9) cell lines
Concentrations：0-25 μM
Incubation Time：14-20 days
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | 날짜 | 항목 |
|---|---|---|---|
 J2214434 | Certificate of Analysis | Jul 10, 2025 | C413962 |
| J2214435 | Certificate of Analysis | Jul 10, 2025 | C413962 |
| J2214436 | Certificate of Analysis | Jul 10, 2025 | C413962 |
| J2214460 | Certificate of Analysis | Jul 10, 2025 | C413962 |
| J2214461 | Certificate of Analysis | Jul 10, 2025 | C413962 |
| K2413037 | Certificate of Analysis | Jun 14, 2022 | C413962 |
| 용해성 | Solubility (25°C) In vitro DMSO: Insoluble; Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO(mg/mL) 최대 용해도 | 10 |
| DMSO(mM) 최대 용해도 | 31.76922833 |
| 물(mg/mL) 최대 용해도 | ＜1 |
| 분자량 | 314.770 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 2 |
| Exact Mass | 314.093 Da |
| Monoisotopic Mass | 314.093 Da |
| Topological Polar Surface Area | 68.500 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 611.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
