10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
CSF1R-IN-1 is a CSF1R inhibitor with an with an IC 50 of 0.5 nM.
In Vitro
CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept. . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mice, 25-35 grams (8-11 weeks old) Dosage: 2 mg/kg IV or 10 mg/kg orally (Per Os) Administration: i.v. or oral Result: I.V.: C max =3.55, T 1/2 =0.87\nP.O.: C max =4.6, T 1/2 =1.8, Bioavailability=64%
IC50& Target:IC50: 0.5 nM (CSF1R)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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