Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Cyclopamine is a Hedgehog ( Hh ) pathway antagonist with an IC 50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
| Isomeric SMILES | C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1 |
|---|---|
| Alternate CAS | 4449-51-8 |
| NSC Number | 734950 |
| MeSH Entry Terms | cyclopamine |
| Molecular Weight | 411.62 |
| Reaxy-Rn | 1228666 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1228666&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Ju Li, Jinmei Zuo, Xiaoyan Lv, Jiahe Ma, Xiaohong Li, Simiao Fu, Jinsheng Sun. (2023) Hedgehog signaling is essential in the regulation of limb regeneration in the Chinese mitten crab, Eriocheir sinensis. FISH & SHELLFISH IMMUNOLOGY, [PMID:37543149] [10.1016/j.fsi.2023.108981] |
| 2. Zhao Ye, Wang Huiling, He Tianhua, Ma Bo, Chen Guoguang, Tzeng Chimeng. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of Cell Communication and Signaling, [PMID:37338798] [10.1007/s12079-023-00775-6] |
| 3. Tingting Lv, Lei Shen, Lei Yang, Wenxiu Diao, Zhenming Yang, Ying Zhang, Shijie Yu, Yanxia Li. (2018) Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via Sonic hedgehog signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:30218952] [10.1016/j.intimp.2018.09.009] |
| 4. Kuiyuan Song, Guanqun Zheng, Yue Zhao. (2018) Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway. CELL BIOLOGY INTERNATIONAL, 42 (8): (994-1005). [PMID:29573522] [10.1002/cbin.10965] |
| 5. Sha Feng, Jue Liu, Biao Cheng, Aiping Deng, Hong Zhang. (2018) (-)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway. Experimental and Therapeutic Medicine, 15 (5): (4284-4290). [PMID:29731823] [10.3892/etm.2018.5936] |
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