D-3 - ≥99% , CAS No.1967815-98-0

CAS: 1967815-98-0 Cat. No.: D651496 분자식: C₄₈H₄₇N₄O₁₀P 분자량: 870.88

등급 & 순도 ≥99%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

In Vitro

D-3 prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay. D-3 induces obvious loss of viability in 201B7 cells, with half maximal inhibitory concentration value of 192.3 ± 57.4 μM. D-3 induces an increase in the amount of activated elF2a, p38, and p44/42 MAPK, which\nare activated in response to cellular stress. D-3 also increases the number of Annexin-V and SYTOX-positive cells, indicating apoptotic and dead cells after D-3 treatment. D-3 has little influence on various non-iPSCs, including hepatocytes and neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Six human iPSCs lines and one human ESC line (khES1). Concentration: 400 μM. Incubation Time: 1-2 h. Result: Sufficient to induce a viability loss (>99% in all iPSC lines and >95% in khES1).

Form:Solid

사양

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.

보관 조건

Protected from light,Argon charged,Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

분자량

870.88