DBCO-CONH-S-S-NHS ester - ≥97%, used for Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling

CAS: 1435934-53-4 Cat. No.: D648358 분자식: C₂₈H₂₇N₃O₆S₂ 분자량: 565.66 PubChem CID: 98233194

GRADE & PURITY ≥97%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

DBCO-CONH-S-S-COONHS Ester or DBCO-CONH-S-S-NHS ester is a cleavable heterobifunctional linker commonly used in bioconjugation and click chemistry. It features a DBCO group for strain-promoted azide-alkyne cycloaddition (SPAAC) and an NHS ester for coupling to primary amines. Its disulfide bond enables controlled cleavage under reductive conditions, thereby supporting applications in targeted drug delivery and molecular assembly.

Specifications

사양 및 순도

≥97%

생화학 및 생리적 메커니즘

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

애플리케이션

Antibody-Drug Conjugates (ADCs): Functions as a cleavable linker for attaching drugs to antibodies. Bioconjugation: Enables efficient molecular assembly through amine and click chemistry reactions. Protein Labeling: Facilitates protein labeling with vario

보관 조건

Protected from light,Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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순수함

≥97%

이름과 식별자

정식 스마일

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethyldisulfanyl]propanoate

InChIKey

RPNGUSKTYYIUDE-UHFFFAOYSA-N

INCHI

1S/C28H27N3O6S2/c32-24(29-16-18-39-38-17-15-28(36)37-31-26(34)13-14-27(31)35)11-12-25(33)30-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)30/h1-8H,11-19H2,(H,29,32)

이성체 SMILES

C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

PubChem CID

98233194

분자량

565.66

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (176.78 mM; Need ultrasonic)
• 분자량: 565.700 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 565.134 Da
• Monoisotopic Mass: 565.134 Da
• Topological Polar Surface Area: 164.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 992.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1