DDX3-IN-2 - 10mM in DMSO , CAS No.1919828-81-1

CAS: 1919828-81-1 Cat. No.: D656343 분자식: C₂₀H₂₃N₅O 분자량: 349.43

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

DDX3-IN-2 is an active DEADbox polypeptide 3 ( DDX3 ) inhibitor with an IC 50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance

In Vitro

DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg . DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats Dosage: Tail vein injection Administration: 20 mg/kg Result: Possessed excellent biocompatibility, and Wistar rats showed a good tolerance to the dose of 20 mg/kg. Animal Model: Rats Dosage: I.v. bolus injection (Pharmacokinetic Analysis) Administration: 10 mg/kg; 0~25 hours Result: Rapidly eliminated the half-life elimination and the plasmatic clearance values.

IC50& Target:HIV

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

DDX3-IN-2 is an active DEADbox polypeptide 3 ( DDX3 ) inhibitor with an IC 50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 분자량: 349.43