Dehydronitrosonisoldipine - ≥98% , CAS No.87375-91-5

CAS: 87375-91-5 Cat. No.: D649804 분자식: C₂₀H₂₂N₂O₅ 분자량: 370.4 PubChem CID: 71413046

GRADE & PURITY ≥98%

Synonyms

3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrosophenyl)-, methyl2-methylpropyl ester | 2,6-dimethyl-5-(3-methylbutan-2-yloxycarbonyl)-4-(2-nitrosophenyl)pyridine-3-carboxylate | 2,6-Dimethyl-5-{[(3-methylbutan-2-yl)oxy]carbonyl}-4-(2-nitrosophenyl

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Dehydronitrosonisoldipine, a derivative of Nisoldipine , is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders

In Vitro

Dehydronitrosonisoldipine exhibits an IC 50 of 4 μM in the SARM1-dN-expression cells, and decreases the cellular cADPR in cells expressing SARM1, but not in expressing SAM-TIR cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:SARM1, Calcium Channel

Specifications

동의어

3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrosophenyl)-, methyl2-methylpropyl ester | 2,6-dimethyl-5-(3-methylbutan-2-yloxycarbonyl)-4-(2-nitrosophenyl)pyridine-3-carboxylate | 2,6-Dimethyl-5-{[(3-methylbutan-2-yl)oxy]carbonyl}-4-(2-nitrosophenyl

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

Dehydronitrosonisoldipine, a derivative of Nisoldipine ( HY-17402 ), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic

보관 조건

Protected from light,Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

ANTAGONIST

순수함

≥98%

이름과 식별자

• 정식 스마일: CC1=C(C(=C(C(=N1)C)C(=O)OC(C)C(C)C)C2=CC=CC=C2N=O)C(=O)[O-]
• IUPAC Name: 2,6-dimethyl-5-(3-methylbutan-2-yloxycarbonyl)-4-(2-nitrosophenyl)pyridine-3-carboxylate
• InChIKey: KKQILAUVQAVWHF-UHFFFAOYSA-M
• INCHI: 1S/C20H22N2O5/c1-10(2)13(5)27-20(25)17-12(4)21-11(3)16(19(23)24)18(17)14-8-6-7-9-15(14)22-26/h6-10,13H,1-5H3,(H,23,24)/p-1
• 이성체 SMILES: CC1=C(C(=C(C(=N1)C)C(=O)OC(C)C(C)C)C2=CC=CC=C2N=O)C(=O)[O-]
• PubChem CID: 71413046
• 분자량: 370.4

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Pyridinecarboxylic acids Methylpyridines Benzene and substituted derivatives Heteroaromatic compounds Carboxylic acid salts Carboxylic acid esters Carboxylic acids C-nitroso compounds Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives Organic anions
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 4-phenylpyridine - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Methylpyridine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxylic acid ester - Carboxylic acid salt - Carboxylic acid - Organic nitroso compound - Carboxylic acid derivative - C-nitroso compound - Azacycle - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic anion - Aromatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (269.98 mM; Need ultrasonic)