DETA-NONOate - ≥90% , CAS No.146724-94-9

CAS: 146724-94-9 Cat. No.: D1529013 분자식: C₄H₁₃N₅O₂ 분자량: 163.18 EC 번호: 633-925-9

GRADE & PURITY ≥90%

Storage

Protected from light,Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Application：

Diethylenetriamine/nitric oxide adduct has been used as nitric oxide (NO) donor:

to evaluate the direct effects of NO on cell proliferation in ovine trophectoderm (oTr1) cells;

to test its effects on recreating the growth inhibitory effect of NO without the presence of macrophages;

to correlate the outflow function and outflow tract vessel diameter changes with other controls in porcine models.

Specifications

사양 및 순도

≥90%

생화학 및 생리적 메커니즘

Nitric oxide donor. Able to spontaneously release NO (t 1/2 = 20 h). Also releases HNO. Decomposition is dependent on pH. Vasodilatory effects in vitro and in vivo . Cell-permeable.

보관 조건

Protected from light,Argon charged,Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥90%

이름과 식별자

• 정식 스마일: C(CN(CCN)[N+](=NO)[O-])N
• IUPAC Name: (Z)-[bis(2-aminoethyl)amino]-hydroxyimino-oxidoazanium
• InChIKey: YNRCBOXEDICOIX-CLFYSBASSA-N
• INCHI: 1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h10H,1-6H2/b9-7-
• 이성체 SMILES: C(CN(CCN)/[N+](=N/O)/[O-])N
• WGK 독일: 3
• 분자량: 163.18
• Reaxy-Rn: 8140575
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8140575&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic 1,3-dipolar compounds
    • 분류 Allyl-type 1,3-dipolar organic compounds

• Kingdom: Organic compounds
• Superclass: Organic 1,3-dipolar compounds
• 분류: Allyl-type 1,3-dipolar organic compounds
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Allyl-type 1,3-dipolar organic compounds
• Alternative Parents: Organopnictogen compounds Organic zwitterions Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Allyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic zwitterion - Primary amine - Organonitrogen compound - Primary aliphatic amine - Amine - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as allyl-type 1,3-dipolar organic compounds. These are organic 1,3-dipolar compounds with the general structure X=Y+-Z- <-> X--Y+=Z<-> X+-Y-Z-<-> X-=Y-Z+ (X, Z = C, N, or O; Y = N or O).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: Soluble in water
• 감도: Moisture、air and light sensitive
• 분자량: 163.180 g/mol
• XLogP3: -1.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 163.107 Da
• Monoisotopic Mass: 163.107 Da
• Topological Polar Surface Area: 117.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 122.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

참고 문헌

1. Xiao Xiao, Guoyuan Song, Huigai Lu, Wen Zheng, Panpan Meng, Wei Peng, Jing Yang, Miao Wang, Jianyong Zhu, Jiao Wang, Bei Li, Moran Li.  (2025)  Cytochrome bd-II oxidase CyxA promotes the pathogenicity of Klebsiella pneumoniae by resisting oxidative stress.  Virulence,      [PMID:41236911] [10.1080/21505594.2025.2590244]

2. Ye Meng, Liu Xinyu, Peng Zhengxiong, Li Shuaichao, Jia Xiaoyu, Yang Xiyuchen, Jiang Shan, Wang Feng, Yang Xiaobing, Yu Juping, Liu Wei, Gao Xiangdong.  (2026)  Engineered Bacteroides thetaiotaomicron sense gut inflammation and deliver therapeutic molecules to alleviate colitis in mice.  Nature Microbiology,      [PMID:42225846] [10.1038/s41564-026-02378-4]

자주 묻는 질문

How should this product be stored?

Store at ?80 °C, protected from light, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 146724-94-9, the molecular formula is C4H13N5O2, and the molecular weight is 163.18 g/mol. InChIKey YNRCBOXEDICOIX-CLFYSBASSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

What is the purity of this product?

This product is supplied at ≥90% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.